Is Hormone Replacement Therapy (HRT) Right for You? What was once a routinely prescribed treatment in menopausal women, hormone replacement therapy, or HRT, saw a sharp decline in 2002 following a study linking HRT to various health risks, including increased risks of breast cancer, heart attack, and stroke. In recent years, however, we’ve seen an […]
Men’s testosterone levels are declining at alarming rates and here is what you can do about it. Core Medical Group’s staff discusses in this blog why we are seeing lower levels than ever and our recommendations to help boost testosterone levels. If you live in South Florida, like millions of men – keeping up with […]
Sermorelin Acetate growth hormone releasing hormone therapy is less expensive or about 70% of the cost of genetically engineered recombinant human growth hormone therapy because of the high cost of genetically engineered medication. It is medically preferable and safer for the human body to increase the level of human growth hormone and IGF-1 naturally within […]
(1). HRT will stop your hot flushes and sweats Troublesome hot flushes, severe night sweats and headaches causing chronic insomnia are characteristic symptoms of the menopause. These symptoms may last for many years. Apart from being socially embarrassing they result in tiredness and depression because of lack of sleep. These symptoms can almost invariably be […]
Estrogen and Depression The sex difference in rates of psychiatric illness, beginning at puberty and continuing throughout the reproductive years, suggest that the brain’s hormonal environment is what modulates the risk and severity of psychiatric morbidity. Hormones play an integral role in the development and prognosis of psychiatric disorders, which has been gaining increased attention, […]
Pantothenic acid has a long list of uses, although there isn’t enough scientific evidence to determine whether it is effective for most of these uses. People take pantothenic acid for treating dietary deficiencies, acne, alcoholism, allergies, baldness, asthma, attention deficit-hyperactivity disorder (ADHD), autism, burning feet syndrome, yeast infections, heart failure, carpal tunnel syndrome, respiratory disorders, celiac disease, colitis, conjunctivitis, convulsions, and cystitis. It is also taken by mouth for dandruff, depression, diabetic nerve pain, enhancing immune function, improving athletic performance, tongue infections, gray hair, headache, hyperactivity, low blood sugar, trouble sleeping (insomnia), irritability, low blood pressure, multiple sclerosis, muscular dystrophy, muscular cramps in the legs associated with pregnancy or alcoholism, neuralgia, and obesity.
Testosterone esters are less polar than free testosterone. Testosterone esters in oil Injected intramuscularly are absorbed slowly from the lipid phase; thus, testosterone cypionate can be given at intervals of two to four weeks.
Testosterone in plasma is 98 percent bound to a specific testosterone-estradiol binding globulin, and about 2 percent is free. Generally, the amount of this sex-hormone binding globulin in the plasma will determine the distribution of testosterone between free and bound forms, and the free testosterone concentration will determine its half-life.
About 90 of a dose of testosterone is excreted in the urine as glucuronic and sulfuric acid conjugates of tesrtosterone and its metabolites; about 6 percent of a dose is excreted in the feces, mostly in the unconjugated form. Inactivation of testosterone occurs primarily in the liver. Testosterone is metabolized to various 17-keto steroids through two different pathways.
The half-life of testosterone cypionate when Injected intramuscularly is approximately eight days.
In many tissues the activity of testosterone appears to depend on reduction to dihydrotestost-
erone, which binds to cytosol receptor proteins. The steroid-receptor complex is transported to the nucleus where it initiates transcription events and cellular changes related to androgen action.
Testosterone therapy can help reverse the effects of hypogonadism, but it’s unclear whether testosterone therapy would have any benefit for older men who are otherwise healthy. Although some men believe that taking testosterone medications may help them feel younger and more vigorous as they age, few rigorous studies have examined testosterone therapy in men who have healthy testosterone levels — and some small studies have revealed mixed results. For example, in one study healthy men who took testosterone medications increased muscle mass but didn’t gain strength.
Researchers are unlocking the mysteries of how low testosterone is related to men’s overall health. Along the way, they’re uncovering connections between low testosterone and other health conditions. Diabetes, metabolic syndrome, obesity, and high blood pressure have all been linked to testosterone deficiency. Low testosterone isn’t known to cause these health problems, and replacing testosterone […]
In the study, funded in part by drug maker Novo Nordisc, researchers looked the causes of death in almost 2,000 German men aged 20 to 79 years. The men with low testosterone at the start of study, which had an average follow up period of 7 years, had a more than 2.5 times greater risk of dying during the next 10 years compared with men with higher testosterone. These men tended to be older, fatter and had a greater prevalence of diabetes and high blood pressure than the men with higher testosterone levels, Haring said.
This difference was not explained by age, smoking, alcohol intake, level of physical activity or increased waist circumference (a risk factor for diabetes and heart disease), according to researcher author Robin Haring, a Ph.D. student from Ernst-Moritz-Arndt University of Greifswald, Institute for Community Medicine.
Low testosterone levels predicted increased risk of death from cardiovascular disease and cancer but not death of any other single cause, the study found.