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Declining Testosterone Levels in Men Men’s testosterone levels are declining at alarming rates. there is something you can do about it. Core Medical Group’s staff discusses in this blog why we are seeing lower levels than ever. We also give recommendations to help boost testosterone levels.     Over the past few decades, testosterone levels are […]

Sermorelin Acetate Core Medical Group of Florida explains Sermorelin Acetate growth hormone releasing hormone therapy is less expensive. It is less than about 70% of the cost of genetically engineered recombinant human growth hormone therapy. Moreover, it is also  because of the high cost of genetically engineered medication.   It is medically preferable and safer […]

Menopause is a natural phase in a woman’s life, but it can bring along a host of challenging symptoms that affect physical and emotional well-being. Thankfully, Hormone Replacement Therapy can help with an effective solution to alleviate menopausal symptoms and provides numerous other benefits. Let’s delve into the wonders of HRT and its transformative effects […]

Learn how high estrogen levels may cause depression in both men and women   The rates of psychiatric illness show a sex difference. It starts at puberty and continues throughout the reproductive years.   This suggests that the brain’s hormonal environment modulates the risk and severity of psychiatric morbidity. Researchers are focusing on the role […]

Pantothenic acid has a long list of uses, although there isn’t enough scientific evidence to determine whether it is effective for most of these uses. People take pantothenic acid for treating dietary deficiencies, acne, alcoholism, allergies, baldness, asthma, attention deficit-hyperactivity disorder (ADHD), autism, burning feet syndrome, yeast infections, heart failure, carpal tunnel syndrome, respiratory disorders, celiac disease, colitis, conjunctivitis, convulsions, and cystitis. It is also taken by mouth for dandruff, depression, diabetic nerve pain, enhancing immune function, improving athletic performance, tongue infections, gray hair, headache, hyperactivity, low blood sugar, trouble sleeping (insomnia), irritability, low blood pressure, multiple sclerosis, muscular dystrophy, muscular cramps in the legs associated with pregnancy or alcoholism, neuralgia, and obesity.

PHARMACOKINETICS
Testosterone esters are less polar than free testosterone. Testosterone esters in oil Injected intramuscularly are absorbed slowly from the lipid phase; thus, testosterone cypionate can be given at intervals of two to four weeks.

Testosterone in plasma is 98 percent bound to a specific testosterone-estradiol binding globulin, and about 2 percent is free. Generally, the amount of this sex-hormone binding globulin in the plasma will determine the distribution of testosterone between free and bound forms, and the free testosterone concentration will determine its half-life.

About 90 of a dose of testosterone is excreted in the urine as glucuronic and sulfuric acid conjugates of tesrtosterone and its metabolites; about 6 percent of a dose is excreted in the feces, mostly in the unconjugated form. Inactivation of testosterone occurs primarily in the liver. Testosterone is metabolized to various 17-keto steroids through two different pathways.

The half-life of testosterone cypionate when Injected intramuscularly is approximately eight days.

In many tissues the activity of testosterone appears to depend on reduction to dihydrotestost-
erone, which binds to cytosol receptor proteins. The steroid-receptor complex is transported to the nucleus where it initiates transcription events and cellular changes related to androgen action.

Testosterone therapy can help reverse the effects of hypogonadism, but it’s unclear whether testosterone therapy would have any benefit for older men who are otherwise healthy. Although some men believe that taking testosterone medications may help them feel younger and more vigorous as they age, few rigorous studies have examined testosterone therapy in men who have healthy testosterone levels — and some small studies have revealed mixed results. For example, in one study healthy men who took testosterone medications increased muscle mass but didn’t gain strength.

      This post will show about Low Testosterone and Your Health. Researchers are unlocking the mysteries of how low testosterone relates to men’s overall health. Along the way, they’re uncovering connections between low testosterone and other health conditions.   Diabetes, metabolic syndrome, obesity, and high blood pressure all link to testosterone deficiency. Low […]

In the study, funded in part by drug maker Novo Nordisc, researchers looked the causes of death in almost 2,000 German men aged 20 to 79 years. The men with low testosterone at the start of study, which had an average follow up period of 7 years, had a more than 2.5 times greater risk of dying during the next 10 years compared with men with higher testosterone. These men tended to be older, fatter and had a greater prevalence of diabetes and high blood pressure than the men with higher testosterone levels, Haring said.

This difference was not explained by age, smoking, alcohol intake, level of physical activity or increased waist circumference (a risk factor for diabetes and heart disease), according to researcher author Robin Haring, a Ph.D. student from Ernst-Moritz-Arndt University of Greifswald, Institute for Community Medicine.

Low testosterone levels predicted increased risk of death from cardiovascular disease and cancer but not death of any other single cause, the study found.

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